Major Sins

Prophet Muhammad (peace be upon him) said:  Avoid seven harmful sins:  Associating partner with Allah,  unlawfully killing , Sorcery,  engaging in usury (interest), encroaching the property of an orphan, not participating in struggle against falsehood and slandering innocent and chaste believing women. (Al-Bukhari, Muslim)

Prophet Muhammad (peace be upon him)said: The one who is disobedient to his parents, the one who is tyrant and the one who is addicted to drinking shall not enter paradise. (An-Nasai, Darimi)